home *** CD-ROM | disk | FTP | other *** search
- *******************************
- * Epimorphin family signature *
- *******************************
-
- The following proteins have been shown to be evolutionary related [1,2,3]:
-
- - Epimorphin, a mammalian mesenchymal protein which plays an essential role
- in epithelial morphogenesis.
- - Syntaxin A (also known as antigen HPC-1) and syntaxin B which are synaptic
- proteins which may be involved in docking of synaptic vesicles at
- presynaptic active zones.
- - Yeast PEP12 which is required for the transport of proteases to the
- vacuole.
- - Yeast SED5 which is required for the fusion of transport vesicles with the
- Golgi complex.
- - Yeast SSO1 and SSO2 which are required for vesicle fusion with the plasma
- membrane.
-
- The above proteins share the following characteristics: a size ranging from
- 30 Kd to 40 Kd; a C-terminal extremity which is highly hydrophobic and is
- probably involved in anchoring the protein to the membrane; a central, well
- conserved region, which seems to be in a coiled-coil conformation.
-
- The pattern specific for this family is based on the most conserved region of
- the coiled coil domain.
-
- -Consensus pattern: R-x(3)-[LIVM]-x(2)-[LIVM]-E-x(2)-[LIVM]-x-E-[LIVM]-x(2)-
- [LIVM]-F-x(2)-[LIVM]-x(2)-[LIVMF]-V-x(2)-Q-[GQ]-x(2)-
- [LIVM]-[DNQ]-x-[LIVM]-[DE]-x-N
- -Sequences known to belong to this class detected by the pattern: ALL.
- -Other sequence(s) detected in SWISS-PROT: NONE.
- -Last update: October 1993 / First entry.
-
- [ 1] Spring J., Kato M., Bernfield M.
- Trends Biochem. Sci. 18:124-125(1993).
- [ 2] Pelham H.R.B.
- Cell 73:425-426(1993).
- [ 3] Aalto M., Ronne H., Keraenen S.
- EMBO J. 11:4095-4104(1993).
-